Article
Rapid genome wide mapping of phosphine resistance loci by a simple regional averaging analysis in the red flour beetle, Tribolium castaneum.
BMC genomics - 24 Sept 2013
Jagadeesan Rajeswaran, Fotheringham Amelia, Ebert Paul R, Schlipalius David I
Abstract excerpt
BACKGROUND: Next-generation sequencing technology is an important tool for the rapid, genome-wide identification of genetic variations. However, it is difficult to resolve the 'signal' of variations of interest and the 'noise' of stochastic sequencing and bioinformatic errors in the large datasets that are generated. We report a simple approach to identify regional linkage to a trait that requires only two pools...
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