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Article

Rational design of a colorimetric pH sensor from a soluble retinoic acid chaperone.

Journal of the American Chemical Society - 30 Oct 2013

Berbasova Tetyana, Nosrati Meisam, Vasileiou Chrysoula, Wang Wenjing, Lee Kin Sing Stephen, Yapici Ipek, Geiger James H, Borhan Babak

Abstract excerpt

Reengineering of cellular retinoic acid binding protein II (CRABPII) to be capable of binding retinal as a protonated Schiff base is described. Through rational alterations of the binding pocket, electrostatic perturbations of the embedded retinylidene chromophore that favor delocalization of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24059243
DOI: 10.1021/ja404900k
PMCID: PMC4104655

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24059243-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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