Article
Lack of association between the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene polymorphism and the risk of benign prostatic hyperplasia in Caucasian men.
Molecular biology reports - 1 Dec 2013
Karatzas Anastasios, Tzortzis Vassilios, Giannatou Eirini, Gravas Stavros, Zachos Ioannis, Oeconomou Athanassios, Melekos Michael, Tsezou Aspasia
Abstract excerpt
Glucuronidation, mediated by the UDP-glucuronosyltransferase 1A1 (UGT1A1) enzyme, is an important metabolic process during which steroids are converted to more easily excreted compounds in steroid target tissues, such as the prostate. The aim of our study was to investigate the possible correlation between UGT1A1 promoter gene polymorphism and benign prostatic hyperplasia. 421 blood samples were obtained from 138...
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