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Article

Zn2+ regulation of ornithine transcarbamoylase. II. Metal binding site.

Journal of molecular biology - 5 Jan 1990

Kuo L C, Caron C, Lee S, Herzberg W

Abstract excerpt

Two types of conformational changes are mediated in Escherichia coli ornithine transcarbamoylase by the metal ion zinc. Upon binding of zinc in rapid equilibrium, the enzyme undergoes an allosteric transition. In the absence of substrates, the zinc-bound enzyme further undergoes a slow isomerizat...

Topics

Binding Sites
Cloning, Molecular
Escherichia coli
Genes, Bacterial
Kinetics
Mutation
Ornithine Carbamoyltransferase
Valine
Zinc

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2405164
DOI: 10.1016/0022-2836(90)90026-I

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2405164-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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