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Article

Zn2+ regulation of ornithine transcarbamoylase. II. Metal binding site.

Journal of molecular biology - 5 Jan 1990

Kuo L C, Caron C, Lee S, Herzberg W

Abstract excerpt

Two types of conformational changes are mediated in Escherichia coli ornithine transcarbamoylase by the metal ion zinc. Upon binding of zinc in rapid equilibrium, the enzyme undergoes an allosteric transition. In the absence of substrates, the zinc-bound enzyme further undergoes a slow isomerization with a concomitant activity loss. Three metal ions are tightly complexed in the isomerized enzyme as determined by...

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PMID: 2405164
DOI: 10.1016/0022-2836(90)90026-I

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