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Article

Glycoepitopes of staphylococcal wall teichoic acid govern complement-mediated opsonophagocytosis via human serum antibody and mannose-binding lectin.

The Journal of biological chemistry - 25 Oct 2013

Kurokawa Kenji, Jung Dong-Jun, An Jang-Hyun, Fuchs Katharina, Jeon Yu-Jin, Kim Na-Hyang, Li Xuehua, Tateishi Koichiro, Park Ji Ae, Xia Guoqing, Matsushita Misao, Takahashi Kazue, Park Hee-Ju, Peschel Andreas, Lee Bok Luel

Abstract excerpt

Serum antibodies and mannose-binding lectin (MBL) are important host defense factors for host adaptive and innate immunity, respectively. Antibodies and MBL also initiate the classical and lectin complement pathways, respectively, leading to opsonophagocytosis. We have shown previously that Staphylococcus aureus wall teichoic acid (WTA), a cell wall glycopolymer consisting of ribitol phosphate substituted with α-...

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Share to Adaptive Immunity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24045948
DOI: 10.1074/jbc.M113.509893
PMCID: PMC3829409

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