Article
Secondary cell wall polymers of Enterococcus faecalis are critical for resistance to complement activation via mannose-binding lectin.
The Journal of biological chemistry - 2 Nov 2012
Geiss-Liebisch Stefan, Rooijakkers Suzan H M, Beczala Agnieszka, Sanchez-Carballo Patricia, Kruszynska Karolina, Repp Christian, Sakinc Tuerkan, Vinogradov Evgeny, Holst Otto, Huebner Johannes, Theilacker Christian
Abstract excerpt
The complement system is part of our first line of defense against invading pathogens. The strategies used by Enterococcus faecalis to evade recognition by human complement are incompletely understood. In this study, we identified an insertional mutant of the wall teichoic acid (WTA) synthesis gene tagB in E. faecalis V583 that exhibited an increased susceptibility to complement-mediated killing by neutrophils....
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