Article
Mutations in the bglY gene increase the frequency of spontaneous deletions in Escherichia coli K-12.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990
Lejeune P, Danchin A
Abstract excerpt
A strong mutator effect has been observed in Escherichia coli K-12 strains mutated in the bglY gene (27 min). The frequency of point mutations is not modified in bglY mutant strains. In contrast, a strong increase in spontaneous generation of large deletions has been observed in these strains, both for chromosomal markers (10-fold increase of galETK-chlA deletions and 100-fold increase of ptsI-cysK deletions) and...
Topics
- Chromosome Deletion
- DNA, Bacterial
- Escherichia coli
- Genes, Bacterial
- Genotype
- Mutation
- Plasmids
- Restriction Mapping