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Article

Amyotrophic lateral sclerosis: the complex path to precision medicine

27 Jul 2018

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the corticomotorneuronal network responsible for voluntary movement. There are well-established clinical, genetic and pathological overlaps between ALS and frontotemporal dementia (FTD), which together constitute the 'TDP-43 proteinopathies'. An ever-expanding list of genes in which mutation leads to typical ALS have implicated...

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PMID: 30054789
DOI: 10.1007/s00415-018-8983-8

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