Article
Measurement of plasma, serum, and platelet serotonin in individuals with high bone mass and mutations in LRP5.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2014
Lee Grace S, Simpson Christine, Sun Ben-Hua, Yao Chen, Foer Dinah, Sullivan Becky, Matthes Susann, Alenina Natalia, Belsky Joseph, Bader Michael, Insogna Karl L
Abstract excerpt
It has recently been suggested that the low-density lipoprotein receptor-related protein 5 (LRP5) regulates bone mass by suppressing secretion of serotonin from duodenal enterochromaffin cells. In mice with targeted expression of a high bone mass-causing (HBM-causing) LRP5 mutation and in humans with HBM LRP5 mutations, circulating serotonin levels have been reported to be lower than in controls whereas...
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