Article
The genetics of dilated cardiomyopathy: a prioritized candidate gene study of LMNA, TNNT2, TCAP, and PLN.
Clinical cardiology - 1 Oct 2013
Hirtle-Lewis Marika, Desbiens Katia, Ruel Isabelle, Rudzicz Nicholas, Genest Jacques, Engert James C, Giannetti Nadia
Abstract excerpt
BACKGROUND: Dilated cardiomyopathy (DCM), which is characterized by left ventricular enlargement and systolic dysfunction, is divided into cases with a clear predisposing condition (eg, hypothyroidism, chemotherapeutic agents, alcoholism, ischemia) and those of unknown cause (idiopathic DCM). Many cases (20%-35%) of DCM are familial, implicating a genetic contribution to the etiology. More than 30 genes have been...
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