Article
Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.
Genome biology - 1 Jan 2013
Muzzey Dale, Schwartz Katja, Weissman Jonathan S, Sherlock Gavin
Abstract excerpt
BACKGROUND: Candida albicans is a ubiquitous opportunistic fungal pathogen that afflicts immunocompromised human hosts. With rare and transient exceptions the yeast is diploid, yet despite its clinical relevance the respective sequences of its two homologous chromosomes have not been completely resolved. RESULTS: We construct a phased diploid genome assembly by deep sequencing a standard laboratory wild-type...
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