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Cell wall protein variation, break-induced replication, and subtelomere dynamics in Candida glabrata.

Molecular microbiology - 1 Jul 2021

Xu Zhuwei, Green Brian, Benoit Nicole, Sobel Jack D, Schatz Michael C, Wheelan Sarah, Cormack Brendan P

Abstract excerpt

Candida glabrata is an opportunistic pathogen of humans, responsible for up to 30% of disseminated candidiasis. Adherence of C. glabrata to host cells is mediated by adhesin-like proteins (ALPs), about half of which are encoded in the subtelomeres. We performed a de novo assembly of two C. glabrata strains, BG2 and BG3993, using long single-molecule real-time (SMRT) reads, and constructed high-quality...

Topics

Candida glabrata
Candidiasis
Cell Adhesion
Cell Adhesion Molecules
Gene Expression Regulation, Fungal
Genome, Fungal
Humans
Polymorphism, Single Nucleotide
Recombination, Genetic
Telomere

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33713372
DOI: 10.1111/mmi.14707

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