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Article

OIM and related animal models of osteogenesis imperfecta.

Connective tissue research - 1 Jan 1995

Shapiro J R, Mcbride D J, Fedarko N S

Abstract excerpt

Osteogenesis imperfecta (OI) is characterized by fragile bones, skeletal deformity, and growth retardation. This heritable disorder of connective tissue is the result of mutations affecting the COL1A1 and COL1A2 genes of type I collagen. Progress in OI research has been limited because of dependence on human fibroblast and osteoblast specimens and the absence of a naturally occurring animal model for this genetic...

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Identifiers

PMID: 15612365
DOI: 10.3109/03008209509010820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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