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Article

Androgen receptor mutations are associated with altered epigenomic programming as evidenced by HOXA5 methylation.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - 1 Jan 2011

Bens S, Ammerpohl O, Martin-Subero J I, Appari M, Richter J, Hiort O, Werner R, Riepe F G, Siebert R, Holterhus P-M

Abstract excerpt

Male external genital differentiation is accompanied by implementation of a long-term, male-specific gene expression pattern indicating androgen programming in cultured genital fibroblasts. We hypothesized the existence of an epigenetic background contributing to this phenomenon. DNA methylation levels in 2 normal scrotal fibroblast strains from 46,XY males compared to 2 labia majora fibroblast strains from 46,XY...

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Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 21311178
DOI: 10.1159/000323807

Genes

HOXA5

Provenance

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