Conferring the ability to utilize inorganic polyphosphate on ATP-specific NAD kinase.

Abstract excerpt

NAD kinase (NADK) is a crucial enzyme for production of NADP⁺. ATP-specific NADK prefers ATP to inorganic polyphosphate [poly(P)] as a phosphoryl donor, whereas poly(P)/ATP-NADK utilizes both ATP and poly(P), and is employed in industrial mass production of NADP⁺. Poly(P)/ATP-NADKs are distributed throughout Gram-positive bacteria and Archaea, whereas ATP-specific NADKs are found in Gram-negative α- and...

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