Article
A negative feedback loop that limits the ectopic activation of a cell type-specific sporulation sigma factor of Bacillus subtilis.
PLoS genetics - 1 Sept 2011
Serrano Mónica, Real Gonçalo, Santos Joana, Carneiro Jorge, Moran Charles P, Henriques Adriano O
Abstract excerpt
Two highly similar RNA polymerase sigma subunits, σ(F) and σ(G), govern the early and late phases of forespore-specific gene expression during spore differentiation in Bacillus subtilis. σ(F) drives synthesis of σ(G) but the latter only becomes active once engulfment of the forespore by the mother cell is completed, its levels rising quickly due to a positive feedback loop. The mechanisms that prevent premature...
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