Article
A novel estrogen receptor-microRNA 190a-PAR-1-pathway regulates breast cancer progression, a finding initially suggested by genome-wide analysis of loci associated with lymph-node metastasis.
Human molecular genetics - 15 Jan 2014
Chu Hou-Wei, Cheng Chun-Wen, Chou Wen-Cheng, Hu Ling-Yueh, Wang Hsiao-Wei, Hsiung Chia-Ni, Hsu Huan-Ming, Wu Pei-Ei, Hou Ming-Feng, Shen Chen-Yang, Yu Jyh-Cherng
Abstract excerpt
To identify microRNAs that are important in regulating breast cancer progression, the present study used data for the 199 961 single-nucleotide polymorphisms (SNPs) in 837 breast cancer patients genotyped in a recent genome-wide association study to identify loci associated with lymph node metastasis (LNM). SNPs tagging the 15q22.2 locus showed a significant association with LNM and miR-190a was found to be the...
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