Article
Evidence for phenotypic bistability resulting from transcriptional interference of bvgAS in Bordetella bronchiseptica.
Molecular microbiology - 1 Nov 2013
Mason Eliza, Henderson Michael W, Scheller Erich V, Byrd Matthew S, Cotter Peggy A
Abstract excerpt
Bordetella species cause respiratory infections in mammals. Their master regulatory system BvgAS controls expression of at least three distinct phenotypic phases in response to environmental cues. The Bvg⁺ phase is necessary and sufficient for respiratory infection while the Bvg⁻ phase is required for survival ex vivo. We obtained large colony variants (LCVs) from the lungs of mice infected with B. bronchiseptica...
Topics
- Animals
- Bacterial Proteins
- Bordetella Infections
- Bordetella bronchiseptica
- Disease Models, Animal
- Escherichia coli
- Feedback, Physiological
- Gene Expression Regulation, Bacterial
- Humans
- Lung
- Mice
- Mice, Inbred BALB C
- Phenotype