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Article

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2006

Roper Randall J, Baxter Laura L, Saran Nidhi G, Klinedinst Donna K, Beachy Philip A, Reeves Roger H

Abstract excerpt

Trisomy 21 is the cause of Down [corrected] syndrome (DS) which is characterized by a number of phenotypes, including a brain which is small and hypocellular compared to that of euploid individuals. The cerebellum is disproportionately reduced. Ts65Dn mice are trisomic for orthologs of about half...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16432181
DOI: 10.1073/pnas.0510750103
PMCID: PMC1360600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16432181-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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