Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog.

Mechanisms of development - 1 Jan 2000

Roper Randall J, VanHorn Justin F, Cain Colyn C, Reeves Roger H

Abstract excerpt

Trisomy 21 results in phenotypes collectively referred to as Down syndrome (DS) including characteristic facial dysmorphology. Ts65Dn mice are trisomic for orthologs of about half of the genes found on human chromosome 21 and exhibit DS-like craniofacial abnormalities, including a small dysmorphic mandible. Quantitative analysis of neural crest (NC) progenitors of the mandible revealed a paucity of NC and a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Branchial Region
Share to Down Syndrome
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Mitosis

Share to Neural Crest

Share to Neural Tube

Share to Trisomy

Source

Open in PubMed Open full text

Identifiers

PMID: 19056491
DOI: 10.1016/j.mod.2008.11.002
PMCID: PMC2820727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog.PMID 19056491Read ↗

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice.Semantic proximity Read ↗

A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome.Semantic proximity Read ↗

Craniofacial dysmorphology in Down Syndrome is caused by increased dosage of Dyrk1a and at least three other genesSemantic proximity Read ↗

Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down SyndromeSemantic proximity Read ↗

Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndromeSemantic proximity Read ↗

Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes.Semantic proximity Read ↗

Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation.Semantic proximity Read ↗

Cell Cycle Elongation Impairs Proliferation of Cerebellar Granule Cell Precursors in the Ts65Dn Mouse, an Animal Model for Down SyndromeSemantic proximity Read ↗

Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome.Semantic proximity Read ↗

Defects in Embryonic Neurogenesis and Initial Synapse Formation in the Forebrain of the Ts65Dn Mouse Model of Down SyndromeSemantic proximity Read ↗

Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndrome.Semantic proximity Read ↗

Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.