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Article

Prohibitin-2 binding modulates insulin-like growth factor-binding protein-6 (IGFBP-6)-induced rhabdomyosarcoma cell migration.

The Journal of biological chemistry - 11 Oct 2013

Fu Ping, Yang Zhiyong, Bach Leon A

Abstract excerpt

Insulin-like growth factor (IGF)-binding protein (IGFBP)-6 decreases cancer cell proliferation and survival by inhibiting the effects of IGF-II. More recently, IGFBP-6 was found to promote the migration of rhabdomyosarcoma (RMS) cells in an IGF-independent manner, and MAPK pathways were involved in this process. However, the precise molecular mechanisms of these IGF-independent migratory actions of IGFBP-6 are...

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Topics

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Share to Binding, Competitive
Share to Cell Movement
Share to Chromatography, Affinity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Confocal

Share to Mitogen-Activated Protein Kinases

Share to Prohibitins

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Source

Open in PubMed Open full text

Identifiers

PMID: 24003225
DOI: 10.1074/jbc.M113.510826
PMCID: PMC3795287

Genes

PHB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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