Article
Hematopoietic stem cell mobilization for gene therapy: superior mobilization by the combination of granulocyte-colony stimulating factor plus plerixafor in patients with β-thalassemia major.
Human gene therapy - 1 Oct 2013
Yannaki Evangelia, Karponi Garyfalia, Zervou Fani, Constantinou Varnavas, Bouinta Asimina, Tachynopoulou Varvara, Kotta Konstantina, Jonlin Erica, Papayannopoulou Thalia, Anagnostopoulos Achilles, Stamatoyannopoulos George
Abstract excerpt
Successful stem cell gene therapy requires high numbers of genetically engineered hematopoietic stem cells collected using optimal mobilization strategies. Here we focus on stem cell mobilization strategies for thalassemia and present the results of a plerixafor-based mobilization trial with emphasis on the remobilization with granulocyte-colony stimulating factor (G-CSF)+plerixafor in those patients who had...
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