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Article

HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor

28 Aug 2013

Abstract excerpt

The hepatocyte growth factor (HGF) also known as scatter factor activates cancer cell invasion and metastasis. We show that in ovarian cancer cells HGF induced the phosphorylation of the small heat shock protein of 27 kDa (HSP27) by activating the p38MAPK. HSP27 is increased in many cancers at advanced stage including ovarian cancer and associated with cancer resistance to therapy and poor patients' survival. The...

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PMID: 23996744
DOI: 10.1002/ijc.28464

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