Article
Hsp27-induced MMP-9 expression is influenced by the Src tyrosine protein kinase yes.
Biochemical and biophysical research communications - 23 Mar 2001
Hansen R K, Parra I, Hilsenbeck S G, Himelstein B, Fuqua S A
Abstract excerpt
The small heat shock protein hsp27 is associated with aggressive tumor behavior in certain subsets of breast cancer patients. Previously we demonstrated that hsp27 overexpression in breast cancer cells increased in vitro and in vivo invasiveness, suggesting that hsp27 influences the metastatic process. To investigate this role for hsp27, we have utilized MDA-MB-231 breast cancer cells that overexpress hsp27 and...
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