Article
Metabolic block at early stages of the glycolytic pathway activates the Rcs phosphorelay system via increased synthesis of dTDP-glucose in Escherichia coli.
Molecular microbiology - 1 Feb 2004
El-Kazzaz Waleed, Morita Teppei, Tagami Hideaki, Inada Toshifumi, Aiba Hiroji
Abstract excerpt
A mutational block in the early stages of the glycolytic pathway facilitates the degradation of the ptsG mRNA encoding the major glucose transporter IICBGlc in Escherichia coli. The degradation is RNase E dependent and is correlated with the accumulation of either glucose-6-P or fructose-6-P (Kimata et al., 2001, EMBO J 20: 3587-3595; Morita et al., 2003, J Biol Chem 278: 15608-15614). In this paper, we...
Topics
- Bacterial Proteins
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Gene Silencing
- Genes, Bacterial
- Glucose
- Glucose-6-Phosphate
- Glucose-6-Phosphate Isomerase
- Glucosephosphate Dehydrogenase