Article
In vitro and in vivo models for analysis of resistance to anticancer molecular therapies.
Current medicinal chemistry - 1 Jan 2014
Rosa Roberta, Monteleone Francesca, Zambrano Nicola, Bianco Roberto
Abstract excerpt
The efficacy of classical and molecular therapies in cancer is hampered by the occurrence of primary (intrinsic) and secondary (acquired) refractoriness of tumours to selected therapeutic regimens. Nevertheless, the increased knowledge of the genetic, molecular and metabolic mechanisms underlying cancer results in the generation of a correspondingly increasing number of druggable targets and molecular drugs....
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