Article
Increased serum IgG and IgA in overweight children relate to a less favourable metabolic phenotype.
Pediatric obesity - 1 Jun 2014
Bassols J, Prats-Puig A, Gispert-Saüch M, Crehuet-Almirall M, Carreras-Badosa G, Díaz-Roldán F, Montesinos-Costa M, de Zegher F, Ibáñez L, López-Bermejo A
Abstract excerpt
BACKGROUND: The adaptive immune system has emerged as an unexpected modulator of insulin resistance. B lymphocytes accumulate in adipose tissue and produce pathogenic antibodies that cause insulin resistance. OBJECTIVE: We studied whether circulating immunoglobulins (IgG, IgA and IgM) were related to metabolic risk markers in pre-pubertal children with and without overweight. DESIGN AND METHODS: Subjects were 270...
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