Article
[Association of epithermal growth factor receptor expression and its downstream gene mutation status with radiosensitivity of colorectal carcinoma cell lines in vitro].
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery - 1 Aug 2013
Zuo Zhi-gui, Yu Zhi-qi, Gao Xian-hua, Wang Hao, Zhang Chang, Liu Qi-zhi, Han Yi-fang, Chen Li-ping, Zhang Xiao-qing, Fu Chuan-gang
Abstract excerpt
OBJECTIVE: To investigate the effect of epithermal growth factor receptor (EGFR) expression and K-ras, B-raf and PIK3CA mutation status on the radiosensitivity of human colorectal carcinoma (CRC) cell lines in vitro. METHODS: Real-time RT-PCR was used to measure EGFR mRNA expression in nine human CRC cell lines, and K-ras, B-raf and PIK3CA mutation status of each CRC cell line was also identified respectively....
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