Article
Identification of cross-clade CTL epitopes in HIV-1 clade A/E-infected individuals by using the clade B overlapping peptides.
Microbes and infection - 1 Nov 2013
Watanabe Koji, Murakoshi Hayato, Tamura Yoshiko, Koyanagi Madoka, Chikata Takayuki, Gatanaga Hiroyuki, Oka Shinichi, Takiguchi Masafumi
Abstract excerpt
Identification of cross-clade T cell epitopes is one of key factors for the development of a widely applicable AIDS vaccine. We here investigated cross-clade CD8(+) T cell responses between clade B and A/E viruses in chronically HIV-1 clade A/E-infected Japanese individuals. CD8(+) T cell responses to 11-mer overlapping peptides derived from Nef, Gag, and Pol clade B consensus sequences were at a similar level to...
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