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Article

Genetic susceptible locus in NOTCH2 interacts with arsenic in drinking water on risk of type 2 diabetes.

PloS one - 1 Jan 2013

Pan Wen-Chi, Kile Molly L, Seow Wei Jie, Lin Xihong, Quamruzzaman Quazi, Rahman Mahmuder, Mahiuddin Golam, Mostofa Golam, Lu Quan, Christiani David C

Abstract excerpt

BACKGROUND: Chronic exposure to arsenic in drinking water is associated with increased risk of type 2 diabetes mellitus (T2DM) but the underlying molecular mechanism remains unclear. OBJECTIVES: This study evaluated the interaction between single nucleotide polymorphisms (SNPs) in genes associated with diabetes and arsenic exposure in drinking water on the risk of developing T2DM. METHODS: In 2009-2011, we...

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Topics

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Share to Arsenic
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drinking Water

Share to Environmental Exposure

Share to Gene-Environment Interaction

Share to Genetic Loci

Share to Receptor, Notch2

Share to Water Pollutants, Chemical

Source

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Identifiers

PMID: 23967108
DOI: 10.1371/journal.pone.0070792
PMCID: PMC3743824

Genes

NOTCH2
ADAMTS9

Provenance

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