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Cytotoxic Psammaplysin Analogues from a <i>Suberea</i> sp. Marine Sponge and the Role of the Spirooxepinisoxazoline in Their Activity

21 Aug 2013

Abstract excerpt

Seventeen bromotyrosine-derived metabolites, including eight new compounds, were isolated from a Micronesian sponge of the genus Suberea. Four of the new compounds were psammaplysin derivatives (10-13), and the other four were ceratinamine derivatives (14-17). Of the compounds obtained, the psammaplysins exhibited cytotoxicity against human cancer cell lines (GI₅₀ values down to 0.8 μM), while the ceratinamine...

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PMID: 23964644
DOI: 10.1021/np400448y

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