Aaptamines from the Marine Sponge<i>Aaptos</i>sp. Display Anticancer Activities in Human Cancer Cell Lines and Modulate AP-1-, NF-<i>κ</i>B-, and p53-Dependent Transcriptional Activity in Mouse JB6 Cl41 Cells

Abstract excerpt

Aaptamine (8,9-dimethoxy-1H-benzo[de][1,6]naphthyridine) is a marine natural compound possessing antioxidative, antimicrobial, antifungal, and antiretroviral activity. Earlier, we have found that aaptamine and its derivatives demonstrate equal anticancer effects against the human germ cell cancer cell lines NT2 and NT2-R and cause some changes in the proteome of these cells. In order to explore further the...

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