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Article

Cytotoxic Cyclic Depsipeptides from the Australian Marine Sponge <i>Neamphius huxleyi</i>

6 Dec 2012

Abstract excerpt

Three new cyclic depsipeptides, neamphamides B (2), C (3), and D (4), were isolated from the Australian sponge Neamphius huxleyi. The planar structural characterization of these molecules was elucidated using 2D NMR experiments and ESI-FTICR-MS(n). Their configurations were determined by Marfey's method and J-based NMR analysis. These new metabolites inhibited the growth of human cell lines (A549, HeLa, LNCaP,...

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PMID: 23215348
DOI: 10.1021/np3006474

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