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Cytotoxic Activity of Indole Alkaloids from Alstonia macrophylla

1 May 1999

Abstract excerpt

Thirteen indole alkaloids isolated from the root bark of Alstonia macrophylla and a semisynthetic bisindole O-acetylmacralstonine have been assessed for cytotoxic activity against two human lung cancer cell lines, MOR-P (adenocarcinoma) and COR-L23 (large cell carcinoma), using the SRB assay. Pronounced cytotoxic activity was exhibited by the bisindoles on both cell lines. This suggests that, in comparison with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10364834
DOI: 10.1055/s-1999-13992

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