Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dna2 is involved in CA strand resection and nascent lagging strand completion at native yeast telomeres.

The Journal of biological chemistry - 11 Oct 2013

Budd Martin E, Campbell Judith L

Abstract excerpt

Post-replicational telomere end processing involves both extension by telomerase and resection to produce 3'-GT-overhangs that extend beyond the complementary 5'-CA-rich strand. Resection must be carefully controlled to maintain telomere length. At short de novo telomeres generated artificially by HO endonuclease in the G2 phase, we show that dna2-defective strains are impaired in both telomere elongation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to DNA Breaks, Double-Stranded
Share to DNA, Single-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Agar Gel

Share to Endodeoxyribonucleases

Share to Exodeoxyribonucleases

Share to S Phase

Share to Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 23963457
DOI: 10.1074/jbc.M113.472456
PMCID: PMC3795242

Genes

FEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dna2 is involved in CA strand resection and nascent lagging strand completion at native yeast telomeres.PMID 23963457Read ↗

Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres.Semantic proximity Read ↗

A Critical Role for Dna2 at Unwound Telomeres.Semantic proximity Read ↗

Disease-associated DNA2 nuclease-helicase protects cells from lethal chromosome under-replication.Semantic proximity Read ↗

Limiting homologous recombination at stalled replication forks is essential for cell viability: DNA2 to the rescueSemantic proximity Read ↗

The endonuclease activity of the yeast Dna2 enzyme is essential in vivo.Semantic proximity Read ↗

Differential processing of leading- and lagging-strand ends at Saccharomyces cerevisiae telomeres revealed by the absence of Rad27p nuclease.Semantic proximity Read ↗

Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication.Semantic proximity Read ↗

Proofreading activity of DNA polymerase Pol2 mediates 3'-end processing during nonhomologous end joining in yeast.Semantic proximity Read ↗

Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast.Semantic proximity Read ↗

Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability.Semantic proximity Read ↗

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.Semantic proximity Read ↗

The MRX complex plays multiple functions in resection of Yku- and Rif2-protected DNA ends.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.