Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.

The Journal of biological chemistry - 4 Oct 2013

Combs Michelle D, Knutsen Russell H, Broekelmann Thomas J, Toennies Holly M, Brett Thomas J, Miller Chantel A, Kober Daniel L, Craft Clarissa S, Atkinson Jeffrey J, Shipley J Michael, Trask Barbara C, Mecham Robert P

Abstract excerpt

Microfibril-associated glycoprotein (MAGP) 1 and 2 are evolutionarily related but structurally divergent proteins that are components of microfibrils of the extracellular matrix. Using mice with a targeted inactivation of Mfap5, the gene for MAGP2 protein, we demonstrate that MAGPs have shared as well as unique functions in vivo. Mfap5(-/-) mice appear grossly normal, are fertile, and have no reduction in life...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Proteins
Share to Contractile Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Pleiotropy

Share to Leukocyte Count

Share to Neutropenia

Share to Neutrophils

Share to RNA Splicing Factors

Share to RNA Stability

Source

Open in PubMed Open full text

Identifiers

PMID: 23963447
DOI: 10.1074/jbc.M113.497727
PMCID: PMC3789982

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.PMID 23963447Read ↗

Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease.Semantic proximity Read ↗

Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.Semantic proximity Read ↗

Identification of a Matrix-binding Domain in MAGP1 and MAGP2 and Intracellular Localization of Alternative Splice FormsSemantic proximity Read ↗

The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-β.Semantic proximity Read ↗

Microfibril-associated glycoprotein 4 (Mfap4) regulates haematopoiesis in zebrafish.Semantic proximity Read ↗

Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation.Semantic proximity Read ↗

Marfan syndrome: new clues to genotype-phenotype correlations.Semantic proximity Read ↗

Functional analysis of zebrafish microfibril-associated glycoprotein-1 (Magp1) in vivo reveals roles for microfibrils in vascular development and functionSemantic proximity Read ↗

MFAP5 Loss-of-Function Mutations Underscore the Involvement of Matrix Alteration in the Pathogenesis of Familial Thoracic Aortic Aneurysms and DissectionsSemantic proximity Read ↗

Fibronectin-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndromeSemantic proximity Read ↗

Revised genomic structure of the human MAGP1 gene and identification of alternate transcripts in human and mouse tissues.Semantic proximity Read ↗

Fibulin-5, an integrin-binding matricellular protein: its function in development and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.