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Article

Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.

The Journal of biological chemistry - 12 Sept 2008

Weinbaum Justin S, Broekelmann Thomas J, Pierce Richard A, Werneck Claudio C, Segade Fernando, Craft Clarissa S, Knutsen Russell H, Mecham Robert P

Abstract excerpt

Microfibril-associated glycoprotein-1 (MAGP-1) is a small molecular weight component of the fibrillin-rich microfibril. Gene-targeted inactivation of MAGP-1 reveals a complex phenotype that includes increased body weight and size due to excess body fat, an altered wound healing response in bone and skin, and a bleeding diathesis. Elastic tissues rich in MAGP-1-containing microfibrils develop normally and show...

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Source

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Identifiers

PMID: 18625713
DOI: 10.1074/jbc.M709962200
PMCID: PMC2533084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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