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Article

Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease.

Matrix biology : journal of the International Society for Matrix Biology - 1 Oct 2018

Craft Clarissa S, Broekelmann Thomas J, Mecham Robert P

Abstract excerpt

Microfibril-associated glycoproteins 1 and 2 (MAGP-1, MAGP-2) are protein components of extracellular matrix microfibrils. These proteins interact with fibrillin, the core component of microfibrils, and impart unique biological properties that influence microfibril function in vertebrates. MAGPs bind active forms of TGFβ and BMPs and are capable of modulating Notch signaling. Mutations in MAGP-1 or MAGP-2 have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29524629
DOI: 10.1016/j.matbio.2018.03.006
PMCID: PMC6128786

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