Article
Human α-L-iduronidase uses its own N-glycan as a substrate-binding and catalytic module.
Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 2013
Maita Nobuo, Tsukimura Takahiro, Taniguchi Takako, Saito Seiji, Ohno Kazuki, Taniguchi Hisaaki, Sakuraba Hitoshi
Abstract excerpt
N-glycosylation is a major posttranslational modification that endows proteins with various functions. It is established that N-glycans are essential for the correct folding and stability of some enzymes; however, the actual effects of N-glycans on their activities are poorly understood. Here, we show that human α-l-iduronidase (hIDUA), of which a dysfunction causes accumulation of dermatan/heparan sulfate...
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