Article

RNF13 is a novel interactor of iduronate 2-sulfatase that modifies its glycosylation and maturation

2025-06-21

Abstract excerpt

<h4>ABSTRACT</h4> Mucopolysaccharidosis type II, also known as Hunter syndrome, is a rare and fatal disease caused by mutations in the iduronate 2-sulfatase (IDS) encoding gene. The enzymatically inactive variant proteins lead to pathological accumulation of glycosaminoglycans in the lysosomes, causing dysfunction in multiple organs. IDS is expressed as a precursor protein, and its processing and lysosomal targe...

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Literature Corpus work: 2cf6c208-4422-5c04-8e2d-220a6bfb589a
DOI: 10.1101/2025.06.20.660705

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