Article
Calpastatin gene (CAST) is not associated with late onset sporadic Parkinson's disease in the Han Chinese population.
PloS one - 1 Jan 2013
Zhang Lan, Ding Hui, Wang Dan-Hui, Zhang Yan-Li, Baskys Andrius, Chan Piu, Zhong Yu, Cai Yan-Ning
Abstract excerpt
Recent studies point to an association between the late-onset sporadic Parkinson's disease (PD) and single nucleotide polymorphisms (SNPs) rs1559085 and rs27852 in Ca(2+)-dependent protease calpain inhibitor calpastatin (CAST) gene. This finding is of interest since loss of CAST activity could result in over activated calpain, potentially leading to Ca(2+) dysregulation and loss of substantia nigra neurons in PD....
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