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Article

Validating RNAi phenotypes in Drosophila using a synthetic RNAi-resistant transgene.

PloS one - 1 Jan 2013

Jonchere Vincent, Bennett Daimark

Abstract excerpt

RNA interference (RNAi) is a powerful and widely used approach to investigate gene function, but a major limitation of the approach is the high incidence of non-specific phenotypes that arise due to off-target effects. We previously showed that RNAi-mediated knock-down of pico, which encodes the only member of the MRL family of adapter proteins in Drosophila, resulted in reduction in cell number and size leading...

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Identifiers

PMID: 23950943
DOI: 10.1371/journal.pone.0070489
PMCID: PMC3738578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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