Article
Genetic and nongenetic determinants of cell growth variation assessed by high-throughput microscopy.
Molecular biology and evolution - 1 Dec 2013
Ziv Naomi, Siegal Mark L, Gresham David
Abstract excerpt
In microbial populations, growth initiation and proliferation rates are major components of fitness and therefore likely targets of selection. We used a high-throughput microscopy assay, which enables simultaneous analysis of tens of thousands of microcolonies, to determine the sources and extent of growth rate variation in the budding yeast (Saccharomyces cerevisiae) in different glucose environments. We find...
Topics
- Cell Cycle
- Fermentation
- Genes, Fungal
- Genetic Fitness
- Genetic Variation
- Glucose
- Microscopy
- Models, Biological
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins