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Article

A strategy to model nonmonotonic dose-response curve and estimate IC50.

PloS one - 1 Jan 2013

Zhang Hui, Holden-Wiltse Jeanne, Wang Jiong, Liang Hua

Abstract excerpt

The half-maximal inhibitory concentration IC[Formula: see text] is an important pharmacodynamic index of drug effectiveness. To estimate this value, the dose response relationship needs to be established, which is generally achieved by fitting monotonic sigmoidal models. However, recent studies on Human Immunodeficiency Virus (HIV) mutants developing resistance to antiviral drugs show that the dose response curve...

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Identifiers

PMID: 23936323
DOI: 10.1371/journal.pone.0069301
PMCID: PMC3731310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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