Article
Using complete genome comparisons to identify sequences whose presence accurately predicts clinically important phenotypes.
PloS one - 1 Jan 2013
Hall Barry G, Cardenas Heliodoro, Barlow Miriam
Abstract excerpt
In clinical settings it is often important to know not just the identity of a microorganism, but also the danger posed by that particular strain. For instance, Escherichia coli can range from being a harmless commensal to being a very dangerous enterohemorrhagic (EHEC) strain. Determining pathogenic phenotypes can be both time consuming and expensive. Here we propose a simple, rapid, and inexpensive method of...
Topics
- Base Sequence
- Cluster Analysis
- Computer Simulation
- DNA Probes
- Databases, Genetic
- Dysentery, Bacillary
- Escherichia coli
- Escherichia coli Infections
- Genome, Bacterial
- Phenotype
- Polymerase Chain Reaction