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Article

Partial restoration of macrophage alteration from diet-induced obesity in response to Porphyromonas gingivalis infection.

PloS one - 1 Jan 2013

Richard Guilhem, Trivedi Niraj, Belta Calin, Amar Salomon

Abstract excerpt

Obesity is a chronic inflammatory disease that weakens macrophage innate immune response to infections. Since M1 polarization is crucial during acute infectious diseases, we hypothesized that diet-induced obesity inhibits M1 polarization of macrophages in the response to bacterial infections. Bone marrow macrophages (BMMΦ) from lean and obese mice were exposed to live Porphyromonas gingivalis (P. gingivalis) for...

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Identifiers

PMID: 23922979
DOI: 10.1371/journal.pone.0070320
PMCID: PMC3726386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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