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Article

Abnormal Expression of the ERG Transcription Factor in Prostate Cancer Cells Activates Osteopontin

14 Jun 2011

Abstract excerpt

Osteopontin (OPN) is an extracellular matrix glycophosphoprotein that plays a key role in the metastasis of a wide variety of cancers. The high level of OPN expression in prostate cells is associated with malignancy and reduced survival of the patient. Recent studies on prostate cancer (PCa) tissue have revealed recurrent genomic rearrangements involving the fusion of the 5' untranslated region of a...

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PMID: 21669963
DOI: 10.1158/1541-7786.mcr-10-0537

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Abnormal Expression of the ERG Transcription Factor in Prostate Cancer Cells Activates OsteopontinPMID 21669963Read ↗

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