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Article

Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture Attenuation.

The American journal of tropical medicine and hygiene - 1 Feb 2016

Lehmann Jason S, Corey Victoria C, Ricaldi Jessica N, Vinetz Joseph M, Winzeler Elizabeth A, Matthias Michael A

Abstract excerpt

Leptospirosis is the most common zoonotic disease worldwide with an estimated 500,000 severe cases reported annually, and case fatality rates of 12-25%, due primarily to acute kidney and lung injuries. Despite its prevalence, the molecular mechanisms underlying leptospirosis pathogenesis remain p...

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Identifiers

PMID: 26711524
DOI: 10.4269/ajtmh.15-0401
PMCID: PMC4751964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-26711524-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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