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Article

Lapatinib induces p27<sup>Kip1</sup>-dependent G₁ arrest through both transcriptional and post-translational mechanisms

15 Aug 2013

Abstract excerpt

Lapatinib, a dual EGFR/HER2 tyrosine kinase inhibitor, has been shown to have potent antitumor effects against human breast cancer. Recent studies have shown that lapatinib upregulates p27(Kip1) (here after referred to as p27) expression and induces G₁ cell cycle arrest in various types of cancer cells. However, the regulation of p27 in lapatinib-induced cell cycle arrest is not well studied. Here we demonstrate...

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PMID: 23907131
DOI: 10.4161/cc.25728

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