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Article

The extended abnormalities in lipoprotein metabolism in familial hypercholesterolemia: developing a new framework for future therapies.

International journal of cardiology - 3 Oct 2013

Ooi Esther M M, Barrett P Hugh R, Watts Gerald F

Abstract excerpt

Familial hypercholesterolemia (FH) is a dominantly inherited disorder characterized by marked elevation of plasma low-density lipoprotein (LDL) cholesterol concentrations and premature coronary artery disease (CHD). In addition to impaired LDL receptor-mediated clearance of LDL particles, in vitro and in vivo studies suggest that hepatic oversecretion of apolipoprotein (apo) B may contribute to the...

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Identifiers

PMID: 23907036
DOI: 10.1016/j.ijcard.2013.06.069

Genes

PCSK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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